(±)-EX-527

(±)-EX-527

CAT N°: 10009798
Price:

From 48.00 40.80

EX-527 is an inhibitor of sirtuin 1 (SIRT1; IC50 = 0.098 µM).{48663} It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7 cells.{48664}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
  • Correlated keywords
    • 942622-26-6 EX527 SIRT 1 2 3 P 450 CYP 3A4 2D6 2C9 2C19 1A2 MCF7 SEN 0014196 SEN0014196 Selisistat
  • Product Overview:
    EX-527 is an inhibitor of sirtuin 1 (SIRT1; IC50 = 0.098 µM).{48663} It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7 cells.{48664}

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