(±)-<wbr/>Cromakalim

(±)-Cromakalim

CAT N°: 14601
Price:

From 182.00 154.70

(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 ?M) and cardioprotective (IC50 = 0.03 ?M) effects in rat hearts.{22674} (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro.{22674} It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K+ channel openers with clinical relevance.{22674}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3R,4S)-rel-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
  • Correlated keywords
    • 86776-67-2 vascular diseases ions channels pumps channels/pumps cardiology BRL 34915 antihypertensive ATP-sensitive potassiums SUR2-Kir6 antiischemic cardioprotections activators BRL34915 BRL-34915 BRLs 34915 prototypical ATPs sensitives K+ SUR2 cardioprotective rats hearts relax bladders smooth muscles in vitro cromakalim openers clinicals relevances
  • Product Overview:
    (±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 ?M) and cardioprotective (IC50 = 0.03 ?M) effects in rat hearts.{22674} (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro.{22674} It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K+ channel openers with clinical relevance.{22674}

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