(±)-6-Prenyl<wbr/>naringenin

(±)-6-Prenylnaringenin

CAT N°: 34499
Price:

From 116.00 98.60

(±)-6-Prenylnaringenin ((±)-6-PN) is a flavonoid that has been found in the hop plant, H. lupulus, and has diverse biological activities.{64052,64054} It inhibits the T-type voltage-gated calcium (Cav) channel Cav3.2 and high-voltage-activated calcium currents in whole-cell patch-clamp assays using HEK293 cells (IC50s = 0.912 and 4.765 µM, respectively).{64052} It inhibits proliferation of PC3 and DU145 prostate cancer cells (IC50s = 18.4 and 29.1 µM, respectively).{64054} (±)-6-PN (20 and 30 mg/kg) reduces mechanical allodynia in a mouse model of neuropathic pain induced by partial sciatic nerve ligation.{64052}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
  • Correlated keywords
    • 170662-24-5 Humulus HEK 293 ALR 2 PNG
  • Product Overview:
    (±)-6-Prenylnaringenin ((±)-6-PN) is a flavonoid that has been found in the hop plant, H. lupulus, and has diverse biological activities.{64052,64054} It inhibits the T-type voltage-gated calcium (Cav) channel Cav3.2 and high-voltage-activated calcium currents in whole-cell patch-clamp assays using HEK293 cells (IC50s = 0.912 and 4.765 µM, respectively).{64052} It inhibits proliferation of PC3 and DU145 prostate cancer cells (IC50s = 18.4 and 29.1 µM, respectively).{64054} (±)-6-PN (20 and 30 mg/kg) reduces mechanical allodynia in a mouse model of neuropathic pain induced by partial sciatic nerve ligation.{64052}

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