(±)-Asenapine-<wbr/><sup>13</sup>C-d<sub>3</sub> (hydro<wbr/>chloride)

(±)-Asenapine-13C-d3 (hydrochloride)

CAT N°: 31980
Price:

€634.00 €538.90

(±)-Asenapine-13C-d3 is intended for use as an internal standard for the quantification of (±)-asenapine (Item No. 9000496) by GC- or LC-MS. (±)-Asenapine is an atypical antipsychotic.{41915,41916} It binds to dopamine D1-4, ?-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7 (Kis = 0.03-3.98 nM).{41916} (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and ?2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine (DOI), apomorphine, and clonidine (Item No. 15949), respectively, in rat brain (ED50s = 75, 40, and 85 ?g/kg, respectively).{41915} In vivo, (±)-asenapine (0.05-0.2 mg/kg, s.c.) increases extracellular dopamine levels in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and lateral striatum and suppresses the conditioned avoidance response in rats.{41917} It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg.{41918} Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3aR,12bR)-rel-5-chloro-2,3,3a,12b-tetrahydro-2-(methyl-13C-d3)-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, monohydrochloride
  • Correlated keywords
    • 1217729-73-1 deuterated deuterium GCMS LCMS anti psychotic 5HT extra cellular
  • Product Overview:
    (±)-Asenapine-13C-d3 is intended for use as an internal standard for the quantification of (±)-asenapine (Item No. 9000496) by GC- or LC-MS. (±)-Asenapine is an atypical antipsychotic.{41915,41916} It binds to dopamine D1-4, ?-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7 (Kis = 0.03-3.98 nM).{41916} (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and ?2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine (DOI), apomorphine, and clonidine (Item No. 15949), respectively, in rat brain (ED50s = 75, 40, and 85 ?g/kg, respectively).{41915} In vivo, (±)-asenapine (0.05-0.2 mg/kg, s.c.) increases extracellular dopamine levels in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and lateral striatum and suppresses the conditioned avoidance response in rats.{41917} It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg.{41918} Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder.

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